Interleukin-12 induced interferon-g increases inflammation in acute dextran sulfate sodium induced colitis in mice.

INTRODUCTION The pathogenesis of inflammatory bowel disease (IBD) is still unknown. There is increasing evidence that Th1 cells and their cytokines are implicated in intestinal inflammation. Expression of IFN-gamma has been reported in peripheral blood mononuclear cells and in cells isolated from colon biopsies of patients with IBD [1-7]. In patients with Crohn's disease (CD) greater numbers of IL-2- and IFN-gamma-secreting T cells were [...]