Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

Issey Takehara,Hanano Terashima,Takeshi Nakayama,Takashi Yoshikado,Miwa Yoshida,Ken-ichi Furihata,Nobuaki Watanabe,Kazuya Maeda,Osamu Ando,Yuichi Sugiyama,Hiroyuki Kusuhara

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

2017

Issey Takehara
Hanano Terashima
Takeshi Nakayama
Takashi Yoshikado
Miwa Yoshida
Ken-ichi Furihata
Nobuaki Watanabe
Kazuya Maeda
Osamu Ando
Yuichi Sugiyama
Hiroyuki Kusuhara

Purpose To assess the use of glycochenodeoxycholate-3-sulfate (GCDCA-S) and chenodeoxycholate 3- or 24-glucuronide (CDCA-3G or -24G) as surrogate endogenous substrates in the investigation of drug interactions involving OATP1B1 and OATP1B3.

Keywords:

Drug
Drug interaction
Sulfate
Endogeny
Biochemistry
Chenodeoxycholate
Glucuronide
Chemistry
Drug-drug interaction
Pharmacology
pharmacology toxicology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations