Endurance exercise training blunts the deleterious effect of high-fat feeding on whole body efficiency.

THE MAXIMUM EXTERNAL WORK rate that can be sustained by a muscle or group of muscles is determined by the rate at which adenosine triphosphate (ATP) can be supplied to the myofibrils, with the overwhelming majority of ATP used during sustained exercise being derived from oxidative phosphorylation at the mitochondria. The maximum sustainable rate of mitochondrial ATP supply is, in turn, dependent on the rate of