Evidence for defective immunoglobulin metabolism in severe renal insufficiency.

Abstract:The level of free light chains in normal human serum has been determined as between 2.7 and 7.4 mg/100 ml of serum. The mean kappa (K) to lambda (λ) ratio of the free light chains for this normal population is 1.5, the same ratios found for serum immunoglobulin G (IgG). This is interpreted