Histopathological analysis of chronic gastritis and correlation of pathological features with helicobacter pylori

Introduction: Helicobacter pylori(HP) infection is a major cause of various gastroduodenal pathologies. The objective of our study is to evaluate various histopathological parameters of chronic gastritis using the updated Sydney system and to correlate it with presence of HP. Materials and Method: Total 250 cases of chronic gastritis was evaluated retrospectively from January 2015 to December 2015 in a tertiary care centre. Histopathological examination of all antral gastric biopsies using Hematoxylin and Eosin, and Giemsa stain for grading of various parameters and for detection of HP was carried out. Result: Chronic inflammation was identified in 100% of cases with varying intensity. Intensity of activity showed an incremental trend with density of HP. Forty percent of cases with intestinal metaplasia showed the presence of HP. Atrophy was documented in only one case. A strong association between chronic inflammation, activity, intestinal metaplasia and lymphoid follicle with HP was established. Conclusion: The updated Sydney classification provides an objective mean of classifying chronic gastritis and increases the likelihood of detection of HP. Presence of intense grade of inflammation, activity and lymphoid follicle should hint the histopathologist to search for HP. And also the presence of one of these features is a strong indicator for the presence of the other. Keywords: Chronic gastritis, Helicobacter pylori, Sydney classification