LRRFIP家族的研究进展 Advances in LRRFIP Family

LRRFIP蛋白是能与富含亮氨酸重复序列的FLI (flightless I)蛋白相互作用的分子，参与许多生物学过程，包括作为转录抑制因子抑制TNFα以及NFκB的活性，能与其他蛋白相互作用调控Wnt/β-catenin信号通路进而参与细胞骨架的重排以及作为胞质内外源核酸感受器参与抗病毒过程等。系统进化分析显示，高等哺乳动物中的LRRFIP1和LRRFIP2，以及鱼类中LRRFIP1a，LRRFIP1b和LRRFIP2都是由早期多细胞动物中单一的原始的LRRFIP进化而来。 LRRFIPs was originated as proteins interacting with leucine-rich repeat flightless I gene (FLI); it is involved many functions, including acting as a transcriptional repressor to inhibit TNFα and NFκB activity, interacting with other proteins to regulate Wnt/β-catenin signaling pathway for cytoskel-eton rearrangement, and function as cytosolic nucleic acid sensor against exogenous virus. Phylo-genetic analysis revealed that LRRFIP1 and LRRFIP2 in mammals, LRRFIP1a, LRRFIP1b and LRRFIP2 in fishes are all evolved from single proto LRRFIP in early multicellular organisms.