Inclusion complex of (2)-linalool and b-cyclodextrin

Linalool is a monoterpene alcohol which is present in the essential oils of several aromatic plants. Recent studies suggest that (-)-linalool has antimicrobial, anti- inflammatory, anticancer, antioxidant, and antinociceptive properties in different animal models. The aim of this study was to prepare and characterize inclusion complexes of (-)-linalool with b-cyclodextrin (b-CD). Equimolar binary (-)-linalool/b- CD systems were prepared by physical mixture, paste (PM), and slurry methods (SC) and characterized by differential scanning calorimetry, thermogravimetric analysis, FT-IR spectroscopy, X-ray diffractometry, Karl Fisher titration, and scanning electron microscopy. Thermal characterization indi- cates the occurrence of complexation, mainly in paste com- plexes, which is present in the interval from 140 to 280 Ca gradual mass loss (4.6 %), probably related to (-)-linalool loss. FT-IR spectra showed changes that may be related to the for- mation of intermolecular hydrogen bonds between (-)-linalool and b-CD. The new solid-phase formed using the PM and SC methods, had a crystal structure which was different from the original morphology of b-CD.