The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center

Upon demonstration of the presence of amyloid deposits in tissues, disease typing is necessary for establishing a correct diagnosis, planning a therapeutic strategy, defining the prognosis, and programming genetic counseling. Recent years have witnessed the introduction in the clinical setting of a new resource for the characterization of tissue amyloid deposits: mass spectrometry-based proteomics. Proteomics, centered on the identification of the deposited proteins through mass spectrometry (MS), is being increasingly used by major centers worldwide and allows typing of known as well as novel forms of these diseases.