INTRABEAM intraoperative radiotherapy in breast conserving surgery for early breast cancer

Objective To evaluate the safety and feasibility of INTRABEAM in breast conserving surgery for early stage breast cancer. Methods Clinical data of 43 cases of early breast cancer undergoing INTRABEAM intraopetative radiotherapy from Jan. 2013 to Dec. 2014 were retrospectively analyzed. All cases underwent breast conserving surgery combined with 20 Gy INTRABEAM intraoperative radiotherapy. The postoperative incision, incidence of local complications and acute radiation injury were recorded after surgery. Breast recovery, the cosmetic effects, early overall survival, recurrence-free survival, and non-metastatic survival were followed up. Results All cases were given breast conserving surgery associated with INTRABEAM intraoperative radiotherapy (20 Gy) , with median radiotherapy time of 31 mins ranging from 25 to 39 mins. Five cases underwent postoperative whole breast irradiation. Major early complications included incision infection (1 case) , postoperative effusion (5 cases) , radiation area skin pain (4 cases) . The short-term follow-up survey showed that the satisfaction rate was 93.0%. The overall survival rate, recurrence free survival rate and metastasis free survival rate was 100% respectively. Conclusion Breast conseving surgery combined with INTRABEAM intraoperative radiotherapy for early breast cancer patients is safe and feasible. Key words: INTRABEAM; Breast cancer; Intraoperative radiotherapy; Breast conserving surgery