Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.

Maria Laura Pati,John R. Hornick,Mauro Niso,Francesco Berardi,Dirk Spitzer,Carmen Abate,William G. Hawkins

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.

2017

Maria Laura Pati
John R. Hornick
Mauro Niso
Francesco Berardi
Dirk Spitzer
Carmen Abate
William G. Hawkins

Background Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promising targets for triggering selective pancreatic cancer cells death.

Keywords:

Cancer research
Pathology
Agonist
Medicine
Programmed cell death
Cancer
Pancreatic cancer
Caspase
Reactive oxygen species
Sigma-2 receptor
Receptor
Cytotoxic T cell
Pharmacology
Cancer cell

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