Open-Channel Separation Techniques for the Characterization of Nanomaterials and Their Bioconjugates for Drug Delivery Applications

Open-channel separation techniques can separate samples without reliance on column packing, minimizing sample loss due to adsorption onto the packing materials and reducing damage to samples, in particular, the complexes held together by non-chemical interactions. Field flow fractionation (FFF) and capillary electrophoresis (CE) are two representative open-channel separation techniques. In this chapter, we discuss the use of FFF and CE to separate and characterize various nanomaterials widely applied in biomedical research.