Синтез и биологическая активность водорастворимых полимерных комплексов арбидола

We have synthesized water-soluble complexes between the antiviral drug arbidol (ethyl ester of hydrochloride monohydrate) and polymer compounds with molecular masses of 19 - 31 kDa representing the copolymers of acrylamide (AA) and 2-acrylamido-2-methylpropane sulfonate (AAMPS). The complexes are less toxic than arbidol and retain the high level of antiviral activity of this drug. The content of arbidol in the obtained complexes is within 26.4 - 32.1 mass %. The antiviral activity of the synthesized polymeric complexes against all studied viruses, including human epidemic influenza virus A(H3N2), avian highly pathogenic influenza virus A(H5N1), herpes virus of type I (HSV-I), and adenovirus of type III (AV-III), is comparable to the antiviral effect of the nonmodified arbidol. In vitro toxicity of the obtained complexes is about one order lower compared to that of the nonmodified arbidol, and the pharmacological index is four times that of the initial low-molecular-weight drug. The synthesized water-soluble polymer complexes of arbidol can be useful in the pharmacology, since they can serve the basis for new effective and safe parent antiviral substances and related formulations.