TO FORMULATE THE FIXED DOSE COMBINATION OF CEFEPIME AND AMIKACIN

Pharmacokinetic interactions between beta-lactam and aminoglycoside antibiotics have been studied extensively. Concurrent administration of cefepime and amikacin did not alter the pharmacokinetics of either antibiotic. The values reported for t1/2, CL, CLR, and Vd, for these two antibiotics are very similar. Like most other cephalosporins and aminoglycosides, cefepime and amikacin are minimally metabolized in humans and are primarily excreted in urine in unchanged forms. The CLR values of cefepime and amikacin indicate that these antibiotics are primarily excreted by glomerular filtration. Since cefepime and amikacin are not significantly metabolized, are excreted primarily in urine by the glomerular filtration process, and are poorly bound to serum proteins, as expected the concurrent administration of Cefepime and amikacin would not affect the pharmacokinetics of each other. Cefepime and Amikacin are not compatible with each other because of the solubility problem. To prepare the compatible fixed dose combination of Cefepime and Amikacin .To carry out the quality control of the formulation.