URINARY EXCRETION OF PREGNANDIOL COMPLEX BY MALES III. FOLLOWING INTRAMUSCULAR ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE1

THE PREGNANDIOL COMPLEX has been recovered from the urines of males who had received sodium pregnandiol glucuronide by mouth (i) and of those who had received progesterone instramuscularly (2, 3). This study reports its recovery from the urine of a male who had been given intramuscular injections of desoxycorticosterone acetate.3 A healthy male, 39 years of age, (K. C. in Studies I and II, 1, 3) was given intramuscular injections of desoxycorticosterone acetate in oil as follows: Series I, 5 mg. daily for 5 days; Series II, 10 mg. daily for 5 days. All urine was collected in 24-hour samples, beginning at the time of the first injection and for the subsequent 10 days thereafter. These urines were quantitated by the method of Venning (4) for sodium pregnandiol glucuronide. The results of these studies are given in table 1.