Biology of Osteosarcoma
2014
Unlike other sarcomas, osteosarcoma (OS) is characterized by complex, unbalanced karyotypes and alterations in multiple genes and pathways. This genetic background originates from the high genetic instability of OS cells, which can lead to multiple malignant cell populations within the same tumor (Hattinger et al. 2010; Atiye et al. 2005).
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