Methods and compositions using Klotho fusion polypeptides-FGF

A fusion polypeptide, comprising: (a) a polypeptide comprising at least one extracellular subdomain of Klotho protein one; and (b) a polypeptide comprising a fibroblast growth factor, wherein (i) the Klotho protein is alpha-Klotho and fibroblast growth factor is fibroblast growth factor 23 or variant growth factor fibroblast 23 (R179Q).