Rhodium(III)-catalyzed regio- and stereoselective benzylic α-fluoroalkenylation with gem-difluorostyrenes

Rhodium(III)-catalyzed mild benzylic α-fluoroalkenylation of 8-methylquinolines with gem-difluorostyrenes has been developed. This reaction occurred via C–H activation and C–F cleavage and is applicable to a wide range of substrates, leading to the synthesis of Z-alkenyl fluorides under mild and redox-neutral conditions with high regio- and stereoselectivity.