The carbohydrate metabolic characteristics of patients with diffuse toxic goiter proceeding with an increase in body weight

: Altogether 10 patients (aged 15 to 18) with Basedow's disease, accompanied by a growing body mass were investigated before operation and 5 patients 6 mos. after subtotal strumectomy. Ten patients with Basedow's diseases without body mass increment were taken as controls. A characteristic feature of carbohydrate metabolism in the study group as compared to the control group was hyperinsulinism with normal GTT which was preserved after doing away with thyrotoxicosis. The C-peptide/IRI ratio in patients with Basedow's disease, accompanied by a growing body mass, was decreased as compared to the control group, a tendency towards its increase after subtotal strumectomy was observed. Any differences in the levels of thyroid hormones, TSH and thyroid stimulating blood activity were undetectable.