Response to "Does ALR deficiency pave the way for NASH progression?

We appreciate the important points raised by Weiss et al. Our data indicate that the loss of 21/23 kDa ALR, in mouse and human, renders the liver compromised to develop NASH. Administration of 21/23 kDa ALR to hepatocyte-specific ALR-knockout (ALR- H-KO) mice between 1 and 2 weeks postpartum mitigated steatohepatitis. The 15 kDa ALR is absent (Fig. 8) or expressed at very low level in human liver, and absent in mouse liver. However, further investigation of ALR isoform(s) that can be of therapeutic interventions is important.