Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

Mild heat stress has beneficial effects on organismal health and survival. Here, Kumsta et al. show that a mild heat shock and HSF-1 overexpression induce autophagy in multiple tissues of C. elegans and autophagy-related genes are essential for both heat shock-induced and HSF-1–mediated stress resistance and longevity.