Low-dose oral recombinant interferon-αA in patients with HIV-1 infection : a blinded pilot study
1993
Objective: To evaluate the efficacy of low-dose oral recombinant interferon-α (IFN-αA) on clinical parameters, body weight, CD4+lymphocyte counts and natural killer cell cytolytic activity in HIV-infected patients. Design: Blinded crossover trial with controls for the protein and diluent components of the drug preparation. Setting: Medical school outpatient referral center. Patients, participants: Eight patients with HIV-1 infection and a CD4+ lymphocyte count between 150 and 600×10 6 /l. Concurrent use of zidovudine was permitted
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