Multicomponent Cascade Assembly for Quinolinopyranpyrazole Architectures.

A highly efficient, multicomponent protocol for the construction of functionalized quinolinopyranpyrazole scaffolds with high stereoselectivity has been developed through the application of a domino reaction. All the quinolinopyranpyrazoles were synthesized under solvent- and catalyst-free conditions and required no work-up or column chromatography.