038 MMP-13 INHIBITORS REDUCE NOCICEPTION IN A RAT MODEL OF OSTEOARTHRITIS

fibres) compared to only 8.8±4 action potentials/min (n = 18 fibres) in the AZ12606133 treated cohort (Figure B). Movement-evoked nerve firing in AZ12606133 treated animals was approximately 50% of the control group. Conclusions: Chronic treatment of OA animals with AZ12606133 caused a reduction in articular cartilage destruction as well as attenuating joint nociception. It is possible, therefore, that chondroprotection can have beneficial effects on OA pain severity.