Evaluation ofanEnzymeImmunoassay forDetection of Chlamydia trachomatis inUrineofAsymptomatic Men

staining (DFA)forelementary bodies inurine sediment orinculture transport media. Whenchlamydial infection wasdefined aseither a positive urethral culture orpositive EIAconfirmed byDFA,chlamydia prevalence increased to8.9%Yo in asymptomatic menand11.6%insymptomatic men.Theurine EIAsensitivity, specificity, andpositive and negative predictive values forchlamydia detection inasymptomatic menwere84.8, 99.3, 91.8, and98.5%, respectively, withnearly identical results forsymptomatic men.Thesensitivities ofurethral culture alone compared withthecombination ofurethral culture andurine EIA(with DFAconfirmation) were87.3and 94.3%forasymptomatic andsymptomatic men,respectively. Thepresent ETAofurine sediment isbothhighly sensitive andspecific forthedetection ofC.trachomatis inasymptomatic men,thusproviding anoninvasive screening method forchlamydia infection inasymptomatic menattending sexually transmitted disease clinics.