(R)-[(2-Oxo-4-thiazolidinyl)methyl]triphenylphosphoniumIodide: A Wittig Reagent for the Synthesis of Cysteine-DerivedAlkenes

Christina J. Shaffer,Rulin Fan,Michael D. Lewis,James J. Kowalczyk

(R)-[(2-Oxo-4-thiazolidinyl)methyl]triphenylphosphoniumIodide: A Wittig Reagent for the Synthesis of Cysteine-DerivedAlkenes

2011

Christina J. Shaffer
Rulin Fan
Michael D. Lewis
James J. Kowalczyk

A synthesis of enantiopure cysteine-derived phosphonium reagent (IV), amenable to the kg scale, is developed and its utilization in Wittig reactions is demonstrated.

Keywords:

Reagent
Wittig reaction
Enantiopure drug
Phosphonium
Cysteine
Photochemistry
Organic chemistry
Chemistry
Iodide

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