Simultaneous Quantification ofMesalamine and ItsMetaboliteN-AcetylMesalamine inHuman Plasma by LC-MS/MS and ItsApplication to a BioequivalenceStudy

Liquid chromatographytandem mass spectrometry (LCMS/MS) was used for simultaneous quantification of mesalamineand its metaboliteN-acetyl mesalamine in human plasma with N-acetyl mesalamine D3 as an internal standard (IS). Chromatographic separation was performed on a T