Osteosarcoma in pediatric and young adult patients: The Singapore experience

e21522 Background: There is limited information on treatment and survival regarding these tumors in the South East Asia region. We thus attempted to investigate the incidence, the treatment modalities used and the outcome of OS patients treated at the two major pediatric oncology hospitals in Singapore. Methods: A comprehensive list of patients with OS treated at the Department of Pediatrics National University Hospital and KK Women's and Children's Hospital, Singapore between April 1980 and May 2006 was generated. During the study interval, patients received neoadjuvant chemotherapy followed by definitive surgery consisting of either limb-salvage or amputation followed by adjuvant chemotherapy. Chemotherapy included combination of cisplatin and doxorubicin as per the European Osteosarcoma InterGroup (EOI) and as per the Memorial Sloan-Kettering Cancer Center's (MSKCC) T12 protocols. Treatment of subsequent relapses consisted of various combinations of methotrexate, ifosfamide, etoposide, other, and/or su...