Heterocyclic substituted acylaminothiazole

NEW MATERIAL: A compound of formula I [R 1 represents H, a 1-4C alkyl, phenyl-1-3C alkyl, Z 1 -NR 4 R 5 (Z 1 is a 2-4C alkylene; R 4 and R 5 are H, a 1-4C alkyl, or a saturated heterocycle formed with N) or the like; R 2 represents H, a 1-4C alkyl; R 3 represents a 5-6C cycloalkyl, an aromatic group (phenyl and heteocycle) or the like; R 2 and R 3 may together form formula II (q is 1-4, X p is a halogen, 1-3C alkyl, NO 2 or the like; n is 0-3); Z represents a heterocycle comprising one or more heteroatoms chosen from O, S and N]. EXAMPLE: N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-indole-2-carboxamide. USE: Cholecystokinin and gastrin antagonist substance. PROCESS: An active type of acid of formula III (Z' is Z), or a derivative of Z in which a reacting group is protected, is reacted with an aminoothiazole of formula IV and the protective group is optionally removed, to form the compound of the formula I. COPYRIGHT: (C)1991,JPO