NEGATIVE PRESSURE PULMONARY EDEMA SECONDARY TO UPPER AIRWAY OBSTRUCTION DUE TO RADIOTHERAPY-INDUCED LARYNGEAL EDEMA: A CASE REPORT

SESSION TITLE: Medical Student/Resident Cardiovascular Disease Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: Negative pressure pulmonary edema or post obstructive pulmonary edema occurs due to markedly increased negative intrathoracic pressure due to forced inspiration against a closed glottis1 In adults, it is most commonly caused by infections, tumors, or laryngospasm We present a case of negative pressure pulmonary edema secondary to upper airway obstruction due to radiotherapy-induced laryngeal edema in a young adult CASE PRESENTATION: Our patient is a 54-year-old Caucasian male who presented with complaint of having an acute onset of shortness of breath He had a past medical history of squamous cell carcinoma treated with chemoradiotherapy one year back He was admitted to the hospital two weeks back with complaint of having dysphagia to solids and facial swelling Laryngoscopy at that time reveal arytenoid edema with partially obstructed airway and patient was treated with intravenous steroids with complete resolution of symptoms During this admission, patient was reporting that for the past few days his facial edema and dysphagia have worsened In addition, patient was also having shortness of breath mostly on lying flat and he has recently started sleeping in a recliner Before coming to the hospital, patient had sudden onset shortness of breath and he could not pull air into his chest despite trying hard and heard a high pitched noise from his throat On presentation, patient was requiring oxygen otherwise hemodynamically stable Rapid flu and coronavirus disease 2019 (COVID-19) testing were unremarkable Contrast-enhanced computerized tomography (CT) scan of chest was remarkable for central upper lobe predominant ground-glass opacities Fiber optic flexible laryngoscopy revealed worsened arytenoid edema Patient was diagnosed with negative pressure pulmonary odema secondary to laryngeal narrowing in the supine position in the setting of radiotherapy-induced laryngeal edema Patient was treated with IV steroids with the resolution of symptoms and was transferred to tertiary care setting for tracheostomy DISCUSSION: Negative pressure pulmonary edema can cause acute respiratory failure and should be suspected in patients with laryngeal tumors or infections It is most commonly seen in children due to upper airway infections or in post-operative anesthesia care in the setting of laryngospasm In adults, it can occur due to a wide variety of conditions including angioedema, foreign body aspiration, goiter, and obstructive sleep apnea (OSA) There should be a low threshold of suspicion for this life-threatening emergency which must be treated urgently CONCLUSIONS: Considering the rarity of this condition in medical intensive care units with this being seen in a specific cohort of patients, increased awareness should be spread about this condition Further research is required to better understand the pathophysiology of this disease which will help in prevention Reference #1: Bhattacharya M, Kallet RH, Ware LB, Matthay MA Negative-Pressure Pulmonary Edema Chest 2016;150(4):927-933 doi:10 1016/j chest 2016 03 043 DISCLOSURES: No relevant relationships by Tariq Hassan, source=Web Response No relevant relationships by Haris Zia, source=Web Response