An Entry to Enantioenriched 3,3-Disubstituted Phthalides through Asymmetric Phase-Transfer Catalyzed γ-Alkylation.

A novel asymmetric phase-transfer catalyzed γ-alkylation of phthalide 3-carboxylic esters has been developed, giving access to 3,3-disubstituted phthalide derivatives which present a chiral quatern...