Enzyme-catalyzed regio-selective demethylation of papaverine by CYP105D1

Chen Shen,Wanli Zhao,Xuming Liu,Ji-Hua Liu

Enzyme-catalyzed regio-selective demethylation of papaverine by CYP105D1

2019

Chen Shen
Wanli Zhao
Xuming Liu
Ji-Hua Liu

Objectives To investigate the regio-selective demethylation of papaverine by CYP105D1 and develop a whole-cell biocatalytic system for the preparative synthesis of 6-O-demethyl-papaverine.

Keywords:

Biocatalysis
Enzyme
Molecular biology
Biochemistry
Biology
Cytochrome P450
Papaverine
Catalysis
Demethylation
Stereochemistry
Streptomyces griseus
Regioselectivity
enzyme catalyzed
Biotransformation

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