Derivatives 2-hydroxy-thiophene and furan condensed with a nitrogen cycle on process for the preparation and their therapeutic application.

The invention relates to compounds of formula (CF DRAWING IN BOPI) wherein R1 is selected from R3 and OR3 groups, R is selected from H and group CHR 2 R 'wherein R2 is selected from H, alkyl C1-C4, a -COOR 4 group, Z is S or O; m and n, identical or different, are 1 or 2. The invention also relates to the pro given for the preparation of compounds of formula I as well as pharmaceutical compositions containing them.