Antidiabetic activity of galactomannan from Chinese Sesbania cannabina and its correlation of regulating intestinal microbiota

Abstract The purpose of this study was to evaluate the antidiabetic activity of galactomannan (SP) extracted from endosperm splits of Chinese Sesbania cannabina seeds based on the animal experiments and discuss the effects of SP on the regulation of intestinal microbiota in streptozotocin (STZ) induced diabetic mice. According to the results, we found that the blood glucose and lipids in type 2 diabetes mice decreased significantly with SP treatment. SP was able to increase insulin sensitivity in diabetic mice and improve the intestinal microbiota composition of diabetic mice by the results of high throughput deep sequencing. The improvement of intestinal microbiota could play a vital role in reducing insulin resistance and blood glucose of diabetic mice. The results demonstrated that SP had ability to improve diabetic mellitus and owned the antidiabetic activity. As a consequence, SP could be a potential functional food for reducing blood glucose level and was expected to be suitable for applications in the food and pharmaceutical industries.