Advances in the research on non-nucleos(t)ide chemicals as anti-HBV agents

Current FDA approved drugs for hepatitis B virus(HBV) infection are nucleos(t)ide analogs and immune modulators.However,the use of immune modulators has many side effects while that of nucleos(t)ide analogs can lead to the emergence of resistant viruses.Hence,treatment of chronic hepatitis B remains a clinical challenge.So,new classes of chemicals with novel stuctures and actions against HBV replication arouses much attention.This article summarizes recent research progress of these non-nucleos(t)ide anti-HBV chemicals according to their strcutures and actions.