Der Wert von Mikrohämaturie, Harnzytologie, TPA und Neopterin in der Nachsorge von Blasentumorpatienten

Tumor recurrences were observed 70 times in 715 cystoscopies performed in 253 patients. The sensitivity of microhematuria to detect a tumor recurrence was 61%, the specificity 84%. The sensitivity of microhematuria increased to 90% in Tis and T2 tumors. Urine cytology showed a specificity of 100% and a sensitivity of only 43%. The specificity and sensitivity of TPA was only 58% and 41%, respectively, the latter increased to 80% in Tis. 60 patients with proven tumor recurrence showed an increase of neopterine with higher tumor stage. In tumors of stage T2 and Tis serum neopterine was raised in 90% and urine neopterine in 75%. Based on these results cystoscopy, exfoliative urinary cytology and urine analysis are obligatory in the follow-up of patients with superficial bladder cancer. Because of the low specificity (29–41%) TPA and neopterine are not suitable for follow-up.