Monoclonal Antibodies Against Steroid Receptors and Steroid-Induced Proteins

Estrogens play an important role in the genesis of experimental and human breast cancers1,2. Once established, the tumors are frequently hormone-dependent, i.e. they regress or stop growing if deprived of estrogen3. in humans, about one-third of advanced breast cancers are thus susceptible to remission with endocrine therapy4. Criteria for the selection of patients that will respond to hormonal treatment have been the subject of intense study during the last 2 decades5. On the molecular level this had led to the development of analytical tools for the study of steroid receptors and steroid-induced proteins.