Extramedullary Clonal Hematopoiesis with Indeterminate Potential (E-CHIP)

Clinical Practice Points • We present here the case of an otherwise healthy male patient with paravertebral tumors with histological findings of extramedullary hematopoiesis (EH). • The hematological assessment could not confirm a hematological disease. • Interestingly, both the bone marrow aspirate and the tumor tissue showed positivity for ASXL1 mutation, with variable allele frequency of 30% indicating the finding of extramedullary clonal hematopoiesis of indeterminate potential. • To the best of our knowledge, this is the first description of extramedullary clonal hematopoiesis of indeterminate potential.