New photoaffinity analogs of paclitaxel.

Abstract Two new photoreactive paclitaxel analogs bearing [ 3 H 2 ]-3-(4-benzoyl)phenylpropanoyl group as the photophore as well as radiolabeling unit at the 7 and 10 positions, respectively, are developed. These new photoreactive analogs showed excellent preliminary results on the photoaffinity labeling of tubulin and P-glycoprotein.