Macromolecular systems containing insulin as related to the problem of diabetes

Biological activity of insulin immobilized in a polymer hydrogel modified with inhibitors of proteolytic enzymes was examined in in vitro and in vivo studies. Immobilization of insulin did not affect its biological activity. Oral administration of the immobilized insulin led to a reliably reduced concentration of glucose in the blood of test animals. The efficiency of orally administered preparation amounted to 70-80% of the efficiency of subcutaneously injected native insulin