Temperature-responsive grafted polymer brushes for biomedical application.

Butyl methacrylate and butyl acrylate are two extremely widespread synthetic monomers that have found applications for the fabrication of copolymers for adhesives and coatings. In recent years, there have been noted numerous examples in the applications of PBA (poly(butyl acrylate)) and PBMA (poly(butyl methacrylate)) surfaces and coatings for biomedical applications. For example, soft PBA networks were introduced as polymer networks with adaptable mechanical properties and proposed as soft substrates for the passive mechanical stimulation of some types of cells, which could potentially be used in vivo as implant coatings. PBMA films decorated by end primary amine groups have been successfully used for cell adhesion and the proliferation of renal epithelial cells.