Cell-Mediated Immunity in Pregnancy Evaluated Using Lymphocyte Transformation Tests and Rosette Tests for T and B Lymphocytes

In vitro tests of cellular immune response using lymphocyte transformation tests and rosette tests for T and B lymphocytes were studied in a cross-section analysis of a total of 55 patients in six groups (non-pregnant, 2–3 month pregnant, 4–5 month pregnant, 6–7 month pregnant, at parturition and 3 months after parturition). No pregnancy-related changes were found in the numbers of T, B or nil cells, nor changes in PHA, PWM or MLC responses. However, a significant reversible depression of the PPD response was found in the second half of pregnancy.