Leflunomide‐induced nodulosis in a case of Rheumatoid arthritis

We herein report accelerated nodulosis in a 49-year-old woman with rheumatoid arthritis who was treated with methotrexate and leflunomide. She developed multiple pulmonary and subcutaneous nodules 2 years after the addition of leflunomide to methotrexate. The nodules developed when the rheumatoid arthritis was in remission. The pulmonary nodules regressed following the institution of hydroxychloroquine after stopping leflunomide.