Simultaneous Estimation of Atorvastatin and Ramipril by First Derivative Spectrophotometric method

A simple, precise and economical procedure for the simultaneous estimation of Atorvastatin (ATV) and Ramipril (RAM) in tablet formulation has been developed. ATV is a anticholesteremic agent as well as hydroxymethylglutaryl-CoA reductase inhibitor and RAM is a antihypertensive agent belonging to category of angiotensin-converting enzyme inhibitor. The formulation of Atorvastatin (ATV) and Ramipril (RAM) (Stator-R 5) in a combination mixture is very good pharmacologically since it enhances the efficacy of the individual drugs. The present study involving the simultaneous estimation done by first derivative method. ATV has absorbance maxima at 246nm in methanol and RAM has absorbance maxima at 208nm in methanol. Both these drugs obey Beer’s law in the concentration range employed for the present method. The result of analysis has been validated statistically by recovery studies. The slope and intercept for ATV were -0.00183 and -0.001and for RAM were 0.0036 and -0.046 respectively as determined by the method of least squares. The results were found satisfactory and reproducible. The method was applied successfully for the estimation of ATV and RAM simultaneously in tablet dosage form without the interference of common excipients.