Genetically Diverse PWD/PhJ Mice have Primary Hyperinsulinemia Arising from Enhanced Nutrient-stimulated Insulin Secretion

s / Can J Diabetes 36 (2012) S24eS76 S62 glucolipotoxicity and chronic ER stress. Interestingly, double BaxBak knockout resulted in an acute and transient up-regulation of the islet ER stress response. Together, these data suggest that Bax and Bak, both separately and in combination, are important for beta-cell loss in diabetes and have novel roles in the regulation of beta-cell organelle stress upstream of apoptosis execution.