Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95

This study finds that stimulation of muscarinic acetylcholine receptors causes long-term depression (LTD) of NMDA receptor–mediated synaptic transmission. This LTD requires the release of Ca2+ from IP3-sensitive stores and involves an interaction between the Ca2+ sensor protein hippocalcin, the clathrin adaptor AP2 and NMDA receptors.