TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis

Abstract Background Psoriasis is a common multi-factorial skin disease, in which gene–gene and gene–environment interactions may affect the onset, manifestation and clinical course. Objective To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol intake. Methods Using a two-stage case–control design, we searched for pairwise interactions between cigarette smoking and alcohol intake respectively with 9 single nucleotide polymorphisms (SNPs) at ERAP1 , PTTG1 , CSMD1 , GJB2 , SERPINB8 , ZNF816A and TNIP1/ANXA6 that have been associated with risk for psoriasis in 7,223 subjects. Multiple logistic regression analysis was used for data analysis. Results Significant interactions were found for alcohol intake with rs3762999 ( p  = 0.0257) and rs999556 ( p  = 0.0071) at TNIP/ANXA6 ; and for cigarette smoking with rs7007032 ( p  = 0.0023) and rs10088247 ( p  = 0.0023) at CSMD1. Conclusion This study provides empirical evidence for the gene–environment interactions between TNIP1/ANXA6 and alcohol use, CSMD1 and cigarette smoking, highlighting the importance of gene–environment interactions in the pathogenesis of psoriasis.