Preparation of aFGF-Collagen Sponge and Observation of Its Therapeutic Efficiency

The purpose is to prepare a wound dressing made from aFGF and collagen. The biocompatibility tests and clinical curative effects were detected to evaluate its biological security and clinical effect. aFGF solution was put into purified collagen solution, then becoming sponge by freeze-drying, followed by the biocompatibility tests, including acute toxicity, stimulation, allergy, hemolysis and cell toxicology, as well as the test of implanting in rabbits liver. Then the clinical test of trauma was done.All of biocompatibility tests were negative. The result of implanting test was in gear, and the aFGF-collagen sponge could degrade completely in liver in 8 weeks. The clinical test showed that the aFGF-collagen sponge could not only accelerate the speed of curing but also restrain the trauma extravasation. The aFGF-collagen sponge had good biocompatibility and clinical curative effects. It was suggested to be a security biomaterial for medical use.