Physicochemical and Pharmacokinetic Profiles of Gadopiclenol: A New Macrocyclic Gadolinium Chelate With High T1 Relaxivity

Caroline Robic,Marc Port,Olivier Rousseaux,Stéphanie Louguet,Nathalie Fretellier,Sarah Catoen,Cécile Factor,Soizic Le Greneur,Christelle Medina,Philippe Bourrinet,Isabelle Raynal,Jean Marc Idée,Claire Corot

Physicochemical and Pharmacokinetic Profiles of Gadopiclenol: A New Macrocyclic Gadolinium Chelate With High T1 Relaxivity

2019

Caroline Robic
Marc Port
Olivier Rousseaux
Stéphanie Louguet
Nathalie Fretellier
Sarah Catoen
Cécile Factor
Soizic Le Greneur
Christelle Medina
Philippe Bourrinet
Isabelle Raynal
Jean Marc Idée
Claire Corot

Objectives We aimed to evaluate gadopiclenol, a newly developed extracellular nonspecific macrocyclic gadolinium-based contrast agent (GBCA) having high relaxivity properties, which was designed to increase lesion detection and characterization by magnetic resonance imaging.

Keywords:

Radiology
Nuclear chemistry
Gadolinium-Chelate
Medicine
Pharmacokinetics
Gadolinium
lesion detection
Nuclear magnetic resonance
Magnetic resonance imaging

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