Dose finding study of erlotinib combined to capecitabine and irinotecan in pretreated advanced colorectal cancer patients

Emilio Bajetta,Maria Di Bartolomeo,R. Buzzoni,Erminia Ferrario,Katia Fiorella Dotti,Luigi Mariani,Roberto Bajetta,Arpine Gevorgyan,Paola Venturino,Margherita Galassi

Dose finding study of erlotinib combined to capecitabine and irinotecan in pretreated advanced colorectal cancer patients

2009

Emilio Bajetta
Maria Di Bartolomeo
R. Buzzoni
Erminia Ferrario
Katia Fiorella Dotti
Luigi Mariani
Roberto Bajetta
Arpine Gevorgyan
Paola Venturino
Margherita Galassi

Purpose This study evaluated the maximum tolerated dose (MTD) and the dose limiting toxicity (DLT) of erlotinib when combined to irinotecan and capecitabine in pre-treated metastatic colorectal cancer patients.

Keywords:

Capecitabine
Biochemistry
Cancer
Erlotinib
Phases of clinical research
Colorectal cancer
Tyrosine-kinase inhibitor
Irinotecan
Medicine
Toxicity
Topoisomerase
dose finding

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