Expression of Maspin and uPA in colon cancers and its clinical significance

Objective To investigate the relationship between the expression of Maspin and uPA and the biological behavior in colon cancers.Methods The expression of Maspin and uPA in tumor tissue were detected by immunohistochemical technique in 50 colon cancers and 24 normal colon epithelium.The relationship of the expression with clinicopathological characteristics was statistically analyzed.Results In normal colonic tissues,colonic adenomas and adenocarcinomas,the positive rates of maspin were descending,while the positive rates of uPA were ascending sequentially.The expression of Maspin and uPA were correlated with the depth of invasion,Dukes pathologic stage and lymph node Metastasis.And there were negative correlation between the expression of Maspin and uPA in colonic adenocarcinoma tissues.Conclusion The carcinogenesis,invasion and metastasis of colonic adenocarcinoma maybe correlated with the abnormal expression of Maspin and uPA.They could be valuable tumor markers and prognostic factors for colonic carcinoma,and be potential target for therapies of colonic adenocarcinoma.